The Broad Institute Repurposing Hub: a Small Molecule Toolbox for Interrogating Biological Pathways in Disease Models

Abstract: The Broad Institute's Drug Repurposing Hub is an open-access, curated and annotated collection of FDA- and globally-approved drugs, clinical trial drugs, and pre-clinical tool compounds with a companion information resource. The strength of this collection is the highly-annotated resource including target, mechanisms of action, and indications for each of the 6,800 small molecules. Utilizing this collection as a “toolbox,” scientists can unbiasedly uncover and explore new pathways affecting their biology of interest. In collaboration with the Center for the Development of Therapeutics at the Broad Institute, this unique collection is utilized by scientists in their high-throughput screening campaigns to identify new uses for these highly optimized small molecules in a variety of disease models. Additionally and more importantly, this resource is being used for unbiased exploration of pathways that affect the disease target biology, powering the discovery of new biological insights and disease mechanisms.