Toccata: 'The Data Engine' - From HTS to whole plant High Content Profiling

The Early Discovery Screening workflow at Bayer relies on innovative phenotyping techniques, including High-resolution RGB Imaging, Hyperspectral sensors, and PSII measurements, coupled with high-throughput technologies to generate new chemical starting points. The integration of classical in vivo uHTS and phenotyping ensures robust results. A data workflow, from image acquisition to result visualization, is established to facilitate real-time decision-making for scientists. Data Science approaches, such as Machine Learning and Deep Learning, will assist in hit delegation and the discovery of new parameters and hits of interest. After 18 months of intensive screening, the system will transition from an HT-System to a comprehensive whole-plant high-content profile platform, providing in-depth insights into compound/plant interaction processes with millions of datapoints per trial.