Scientist Johnson and Johnson - Innovative Medicines Toledo, Castilla-La Mancha, Spain
Abstract: Drug discovery is an evolving field and there is always a need to introduce new chemistry in our PMC portfolio in order to enrich our libraries of compounds and drive innovation. Flow chemistry is commonly known for its advantages to access difficult chemical transformation of highly reactive intermediates or reagent which are otherwise not accessible through traditional batch chemistry. 1 In Johnson & Johnson Innovative Medicine we have been broadly using flow chemistry at the discovery level in order to increase the access of sp3 enriched fragment through methodologies such as Negishi, Reformatsky, amide functionalization, photoredox chemistry, etc.2 On the recent years, our focus has been mainly in introducing automated platforms which enable the use of these new methodologies for library synthesis in flow. This approach allows us to screen reaction conditions and synthetize libraries of compounds in flow in an automated manner. Moreover, in our labs we have built up a modular approach using robots in the total sequence from sample preparation to analysis and purification and our flow systems are an integrated part of this workflow and are used for telescoped multistep synthesis combining different batch-flow robots. In this poster, we want to disclose our automated workflow from conditions screenings to reaction execution and compounds submission.3
